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Monika E Hegi Selected Research

Cilengitide

3/2016Cilengitide in newly diagnosed glioblastoma: biomarker expression and outcome.
5/2015Two cilengitide regimens in combination with standard treatment for patients with newly diagnosed glioblastoma and unmethylated MGMT gene promoter: results of the open-label, controlled, randomized phase II CORE study.
9/2014Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial.
11/2012A safety run-in and randomized phase 2 study of cilengitide combined with chemoradiation for newly diagnosed glioblastoma (NABTT 0306).
6/2010Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma.
9/2007Chemoradiotherapy in malignant glioma: standard of care and future directions.

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Monika E Hegi Research Topics

Disease

55Glioblastoma (Glioblastoma Multiforme)
04/2022 - 06/2002
38Neoplasms (Cancer)
04/2022 - 10/2003
25Glioma (Gliomas)
01/2018 - 10/2003
5Brain Neoplasms (Brain Tumor)
04/2022 - 01/2005
4Astrocytoma (Pilocytic Astrocytoma)
11/2016 - 10/2003
4Oligodendroglioma
11/2016 - 02/2006
3Neoplasm Metastasis (Metastasis)
10/2021 - 09/2008
2Infections
11/2016 - 09/2012
2Thrombocytopenia (Thrombopenia)
09/2014 - 09/2012
2Neutropenia
09/2014 - 09/2012
2Necrosis
06/2012 - 10/2003
2Hypoxia (Hypoxemia)
06/2009 - 06/2002
2Carcinogenesis
07/2007 - 10/2004
1Vascular Remodeling
01/2021
1Chronic Hepatitis B
11/2016
1Fatigue
11/2016
1Virus Diseases (Viral Diseases)
11/2016
1HIV Infections (HIV Infection)
11/2016
1Lymphopenia (Lymphocytopenia)
09/2014
1Disease Progression
09/2014
1Leukemia
07/2010
1Meningioma (Meningiomas)
12/2009
1Fanconi Anemia (Fanconi's Anemia)
08/2009
1Breast Neoplasms (Breast Cancer)
08/2009
1Werner Syndrome (Werner's Syndrome)
08/2009
1Inflammation (Inflammations)
06/2009
1Uveal melanoma
09/2008

Drug/Important Bio-Agent (IBA)

28Temozolomide (Temodar)FDA LinkGeneric
04/2022 - 03/2004
16Alkylating AgentsIBA
01/2018 - 03/2004
11MethyltransferasesIBA
01/2019 - 03/2004
8ErbB Receptors (EGF Receptor)IBA
01/2019 - 09/2004
8Biomarkers (Surrogate Marker)IBA
01/2018 - 02/2008
7Proteins (Proteins, Gene)FDA Link
10/2021 - 07/2008
7DNA (Deoxyribonucleic Acid)IBA
01/2019 - 08/2009
7O(6)-Methylguanine-DNA MethyltransferaseIBA
01/2016 - 07/2008
6IntegrinsIBA
03/2016 - 09/2007
6CilengitideIBA
03/2016 - 09/2007
5O-(6)-methylguanineIBA
04/2022 - 09/2008
5Biological ProductsIBA
01/2021 - 01/2007
4TenascinIBA
01/2009 - 10/2004
3Pharmaceutical PreparationsIBA
04/2022 - 12/2012
3Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA
01/2020 - 09/2012
3Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
12/2012 - 10/2003
2A-Form DNA (A-DNA)IBA
04/2022 - 01/2007
2Histones (Histone)IBA
04/2022 - 01/2018
2temsirolimusFDA Link
10/2016 - 09/2007
2TensinsIBA
08/2015 - 01/2005
2ChromatinIBA
01/2015 - 01/2011
2epidermal growth factor receptor VIIIIBA
12/2012 - 06/2011
2Procarbazine (Matulane)FDA Link
09/2012 - 09/2007
2Vincristine (Oncovin)FDA LinkGeneric
09/2012 - 09/2007
2Lomustine (CCNU)FDA Link
09/2012 - 09/2007
2Tyrosine Kinase InhibitorsIBA
06/2011 - 09/2007
2Gefitinib (Iressa)FDA Link
06/2011 - 02/2006
2ParaffinIBA
07/2010 - 07/2008
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
06/2009 - 10/2003
2Fibronectins (Fibronectin)IBA
07/2007 - 10/2004
1InterferonsIBA
10/2021
14- (2- (2- hydroxycyclohexylamino)benzothiazol- 6- yloxy)pyridine- 2- carboxylic acid methylamideIBA
10/2021
1Histone Deacetylase InhibitorsIBA
10/2021
1Interferon-alpha (Interferon Alfa)IBA
10/2021
1Macrophage Colony-Stimulating FactorIBA
10/2021
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2021
1Aldehyde DehydrogenaseIBA
01/2019
1Glucose (Dextrose)FDA LinkGeneric
01/2018
1Ubiquitin-Specific ProteasesIBA
12/2017
1ubiquitin isopeptidaseIBA
12/2017
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
12/2017
1AgarIBA
12/2017
1Transforming Growth Factors (Transforming Growth Factor)IBA
03/2016
1Antimitotic AgentsIBA
12/2015
1B7-H1 AntigenIBA
08/2015
1Immune Checkpoint InhibitorsIBA
08/2015
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
08/2015
1HLA-DR Antigens (HLA-DR)IBA
08/2015
1LigandsIBA
08/2015
1AntigensIBA
12/2012
1AntibodiesIBA
12/2012
1GuanineIBA
01/2011
1Messenger RNA (mRNA)IBA
12/2009
1Transforming Growth Factor beta (TGF-beta)IBA
12/2009
1Growth Differentiation Factor 15IBA
12/2009
1Antineoplastic Agents (Antineoplastics)IBA
08/2009
1Staphylococcal Protein A (Protein A)IBA
01/2009
1Notch2 ReceptorIBA
01/2009
1RNA (Ribonucleic Acid)IBA
09/2008
1lysophosphatidic acidIBA
09/2008
1Platelet-Derived Growth FactorIBA
09/2008
1PaxillinIBA
09/2008
1fotemustine (Muphoran)IBA
09/2008
1Formaldehyde (Formol)FDA Link
07/2008
1Monoclonal AntibodiesIBA
09/2007
1vatalanib (PTK787)IBA
09/2007

Therapy/Procedure

27Therapeutics
10/2021 - 03/2006
19Radiotherapy
11/2016 - 12/2003
16Drug Therapy (Chemotherapy)
11/2016 - 12/2003
8Chemoradiotherapy
10/2016 - 09/2007
2Precision Medicine
09/2010 - 01/2010
1Oral Administration
11/2016
1Palliative Care (Palliative Therapy)
09/2012